The current article focuses on the emerging prospect of chalcone inhibitors that will prevent angiogenic switching by directly inhibiting Matrix metalloproteinases (MMPs)-2/9. This will block neovascularization, vascular formation and network formation by completely depriving the cells of the required nutrient, fluid, signaling molecules and oxygen. The highlighted findings will favorably stimulate young minds, medicinal chemists, future researchers and allied scientists to design or explore prospective MMP-2/9 inhibitors for the treatment of cancer with improved pharmacodynamics features and fewer side or adverse effects.
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